In situ hybridization
Here you will find product flyers and information on our in situ hybridization products, which you can download as PDF files.
Rearrangements of receptor tyrosine kinases (RTK) ALK, ROS1, and RET determine clinically important molecular subgroups of non-small cell lung cancer (NSCLC). About 3 % – 5 % of all NSCLCs show an ALK rearrangement, and 1 % - 2 % show ROS1 or RET rearrangements.
The ZytoPure FISH Probe simultaneously determines the status of the ERBB2 gene and the centromeric alpha satellite sequences of chromosome 17. Amplification of ERBB2 is quite common in breast cancer (appr. 15 % – 20 %) and in gastric cancer, and has been known for many years as a driver mutation.
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