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In situ hybridization


Here you will find product flyers and information on our in situ hybridization products, which you can download as PDF files.

ZytoLight ® probes for the detection of genomic aberrations occuring in sarcomas

Sarcomas are malignant tumours of mesenchymal origin. They are rare with respect to the total population, but account for 10-15 % of all malignant solid tumours in childhood and adolescence.

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ZytoLight ® FISH-probes for the detection of recurrent genomic aberrations in acute and chronic lymphocytic leukaemias.

This flyer gives an overview of Zytomed Systems´ FISH probes for the detection of recurrent genomic aberrations in leukaemias.

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FISH probe panels for hematopathology

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ZytoLight ® und Flex ISH® FISH probes for the detection of recurrent genomic aberrations in lymphomas

Zytomed Systems offers a full range of probes for detection of recurrent aberrations in lymphomas. This flyer provides an overview of our excellent ZytoLight and FlexISH probes.

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HPV in situ hybridization with ZytoFast ®

Until today, more than 200 different types of human papillomavirus (HPV) have been identified. Papilloma viruses infect epithelial cells and are associated with various tissue lesions, ranging from benign warts of skin to malignant tumours.

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Detection of FGFR fusions and amplifications

FGF (fibroblast growth factor) receptors came into the focus of molecular oncology in recent years. There are four FGF receptor tyrosine kinases (FGFR1-4), playing an important role for cell differentiation, cell proliferation, and angiogenesis during normal development.

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ZytoLight ® MET/CEN7 FISH probe for the detection of MET amplifications

The MET gene on chromosome 7 codes for a protein belonging to the family of receptor tyrosine kinases, as do the genes for ALK, ROS1, and RET. As a ligand for this receptor tyrosine kinase the hepatocyte growth factor (HGF) was identified.

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ZytoDot ® 2C CISH to determine the HER status of mamma carcinomas

The ZytoDot® 2C SPEC ERBB2/CEN 17 probe of our sister company ZytoVision enables for the simultaneous detection of the human ERBB2 (HER2) gene and the centromere of chromosome 17 (CEN 17) by means of chromogenic in situ hybridization (CISH) of formalin-fixed tissue specimens.

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ZytoLight ® SPEC ALK/EML4 TriCheckTM probe

Lung cancer results in more cases of death globally than any other type of cancer, therefore the improvement of diagnostics and therapy is of utmost importance.

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