In situ hybridization

Sarcomas are malignant tumours of mesenchymal origin. They are rare with respect to the total population, but account for 10-15 % of all malignant solid tumours in childhood and adolescence.

This flyer gives an overview of Zytomed Systems´ FISH probes for the detection of recurrent genomic aberrations in leukaemias.

Zytomed Systems offers a full range of probes for detection of recurrent aberrations in lymphomas. This flyer provides an overview of our excellent ZytoLight and FlexISH probes.

Until today, more than 200 different types of human papillomavirus (HPV) have been identified. Papilloma viruses infect epithelial cells and are associated with various tissue lesions, ranging from benign warts of skin to malignant tumours.

FGF (fibroblast growth factor) receptors came into the focus of molecular oncology in recent years. There are four FGF receptor tyrosine kinases (FGFR1-4), playing an important role for cell differentiation, cell proliferation, and angiogenesis during normal development.

The MET gene on chromosome 7 codes for a protein belonging to the family of receptor tyrosine kinases, as do the genes for ALK, ROS1, and RET. As a ligand for this receptor tyrosine kinase the hepatocyte growth factor (HGF) was identified.

The ZytoDot^® 2C SPEC ERBB2/CEN 17 probe of our sister company ZytoVision enables for the simultaneous detection of the human ERBB2 (HER2) gene and the centromere of chromosome 17 (CEN 17) by means of chromogenic in situ hybridization (CISH) of formalin-fixed tissue specimens.

Lung cancer results in more cases of death globally than any other type of cancer, therefore the improvement of diagnostics and therapy is of utmost importance.