New NGS-Assay for HRD determination
Detection of mutations in 20 HRR genes and determination of the HRD status
The AmoyDx® HRD Complete Panel is an advanced development of the AmoyDx® HRD Focus Panel, which is already established in many laboratories for determining homologous recombination deficiency (HRD).
In both NGS assays, in addition to the BRCA1/2 mutational status, genomic instability is determined based on 24,000 SNPs, which are evenly distributed throughout the genome. The AmoyDx® HRD Complete Panel can be further used to detect SNVs, InDels and homozygous deletions in 20 genes involved in homologous recombination repair (HRR).
Please find a detailed description of the AmoyDx® HRD Complete Panel here.
This product is for research use only (RUO)
Further topics
Movember 2024
S3 guideline for prostate cancer was updated
In May 2024 the S3 guideline "Prostate Cancer" (version 7.0) was updated. For the first time it is recommended to sequence genes involved in homologous recombination repair (HRR), e. g. ATM, BRCA1/2, BRIP1, CDK12, CHEK2, FANCA, HDAC2 and PALB2, before initiating a systemic therapy for castration-resistant prostate cancer (mCRPC).
